Denamarin contains SAMe which markedly increases liver glutathione levels, a potent antioxidant. SAMe also helps protect liver cells from cell death and may help cell repair and regeneration. Denamarin also has Silybin, the most active part of an extract from milk thistle. Silybin acts as an antioxidant and stimulates the flow of bile through the liver to aid in the digestion and absorption of nutrients from your pet's diet. Silybin also helps with liver cell regeneration and may enhance levels of glutathione, the liver's major "detoxifying" agent.