WASHINGTON (AP) — The United States has imposed sanctions on ​Cuba’s President Miguel Díaz-Canel, along with four other individuals, according to a filing Thursday on the U.S. Treasury Department website.

Included in the sanctions are Alejandro Castro Espín, the son of former President Raúl Castro.

The sanctions come after U.S. President Donald Trump signed an executive order expanding sanctions against the island.

The new sanctions boost pressure on the Cuban government but are far from the first time the U.S. has imposed sanctions against heads of state or government and their relatives.

The U.S. hit former Sudanese President Omar Bashir and former Zimbabwean President Robert Mugabe in the early 2000s and more recently targeted former Venezuelan President Nicolas Maduro and his wife with sanctions.